Parind Desai

Evaluation of segregation intensity of pharmaceutical blends using near infrared spectroscopy

Segregation of components, especially of an active pharmaceutical ingredient (API), in a pharmaceutical blend during secondary manufacturing processes is considered to be one of the major bottlenecks in achieving tablet content uniformity, ultimately leading to batch rejections. The main reasons for segregation such as differences in particle size, density, shapes, solid-solid interactions and segregation induced due to external interferences such as gravitational, shear or vibrational forces are well established, but there are limited tools available to quantify the API segregation intensity at a manufacturing scale. Determining segregation intensity using spectroscopic technique can help in identifying segregation risks early on in product development. This research work focusses on quantifying segregation intensity of pharmaceutical blends using SPECtester (an instrument with an in built near-infrared (NIR) capability).

 

Bio Sketch:

Dr Parind Desai is current working as an investigator in Product & Process Engineering Department at GlaxoSmithKline (GSK). Dr. Desai embeds the material science workflow for GSK projects. Through his application of science and his insightful enhancement of modeling processes, his work guides drug substance and drug product process section and drug product formulation. He evaluates and implements new technologies and ways of working that continue to enhance the performance of plant unit operations. Before joining GSK, Parind completed his Postdoc program from Novartis-MIT Center of Continuous Manufacturing, MIT and PhD from National University of Singapore. His research domains include Material science, continuous and batch processing and formulation development. Dr Desai has achieved the recognition as a pharmaceutical researcher through the publication of scholarly works in influential journals and patents, as well as the presentation of his findings at prestigious international conferences. Parind is also a peer reviewer of pharmaceutical journals like International Journal of Pharmaceutics, Journal of Pharmaceutical Sciences, European Journal of Pharmaceutics and Biopharmaceutics, to name a few.
Evaluation of segregation intensity of pharmaceutical blends using near infrared spectroscopy