Thomas Baxter

Presentation #1
Title: “Separation Anxiety (Part 1): Experimental segregation test methods and their use from development to commercial-scale”
Presenter(s): Thomas Baxter (Director) and Jim Prescott (Vice President), Jenike &Johanson, Inc., Tyngsboro, MA, USA
Abstract: This presentation will focus on bench-scale (500cc to 10cc) segregation test methods and their use from formulation development to trouble-shooting segregation concerns at commercial scale, including the following primary topics:
• Common segregation mechanisms in industrial applications (fluidization, dusting, sifting);
• Bench-scale segregation tests methods (ASTM and material-sparing segregation test methods);
• The use of segregation test data during formulation development (powder beverage and pharmaceutical case histories);
• The use of segregation test data in trouble-shooting segregation concerns at commercial scale, including case histories in the pharmaceutical, food and consumer goods industries.

Presentation #2
Title: “Separation Anxiety (Part 2): Trouble-shooting and solving blend and segregation issues in industrial applications”
Presenter(s): Thomas Baxter (Director) and Jim Prescott (Vice President), Jenike &Johanson, Inc., Tyngsboro, MA, USA
Abstract: This presentation will outline a methodology used to trouble-shoot and develop corrective actions for blending and segregation concerns in a variety of industries, including pharmaceuticals, food and consumer goods. The presentation will cover the following primary topics:
• Methods to collect and analyze stratified blend and content uniformity data (e.g., ISPE guidelines for pharmaceuticals);
• Statistical analysis of blend and content uniformity data and the primary types of variation (e.g., high between location variation, high within location variation, hot spots and outliers);
• Investigative steps during a root cause assessment;
• Common corrective actions to address blending and segregation concerns in industrial applications.

Presenter Biographies

Thomas Baxter, Director, Jenike & Johanson, Inc.
Thomas Baxter joined Jenike & Johanson in 1997. Thomas has focused on pharmaceutical applications, including solving content uniformity problems, maintaining reliable feed and working with clients to develop more robust formulations and process designs, including the design and qualification of a continuous manufacturing process for oral solid dosages. Thomas has also worked on hundreds of projects working with clients to implement cost-effective and efficient material handling systems in the food, specialty chemicals, and energy industries. He has published numerous papers, lectures frequently on the storage and flow of bulk solids and is a member of American Association of Pharmaceutical Scientists (AAPS) and the International Society for Pharmaceutical Engineering (ISPE) working group for blending and feeding in continuous manufacturing. Thomas received his Bachelor’s and Master’s degrees from Virginia Tech, both in engineering mechanics.

James Prescott, Vice President, Jenike & Johanson, Inc.
James joined Jenike & Johanson in 1992. James focus has been primarily on pharmaceutical applications, such as solving and preventing content uniformity problems, maintaining reliable feed, reducing product weight variations, developing specialized feeders for low feed rate/high accuracy applications, and standardizing handling equipment. James has published several articles, lectures frequently and has been awarded patents on equipment related to segregation testing and control. James is a member of American Association of Pharmaceutical Scientists (AAPS), International Society for Pharmaceutical Engineering (ISPE), and was a member of Product Quality Research Institute (PQRI) Blend Uniformity Working Group (BUWG). James received his Bachelor’s degree from Rensselaer Polytechnic Institute and a Master’s degree from Worcester Polytechnic Institute, both in mechanical engineering.